Antibacterial screening notes, from the bench side of the read-out

21 Sep 2026

Buying

StarDrop pricing: what Optibrium charges a year, and what moves the number

Optibrium publishes a range where almost nobody else publishes anything: from about $10,000 a year into six figures. Here is what sits behind that spread, module by module.

17 Sep 2026

Buying

Schrodinger software cost: what a license actually runs, and why nobody publishes the number

Schrodinger publishes no price, and the figure everyone quotes is academic, historical and absent from the live listing. Here is how the licensing actually works and what to budget against.

16 Sep 2026

Buying

Best antibacterial compound libraries for screening, and what each one actually gives you

Four vendors sell a ready-made antibacterial deck and they are two different products. Here is what each contains, which one fits a Gram-negative program, and what the quote hides.

15 Sep 2026

Buying

Antibacterial screening software pricing, and the real cost per compound screened

Almost nobody in this category publishes a price, which makes budgeting a screening cascade harder than it should be. Here is the arithmetic, and what actually moves the number.

10 Sep 2026

Buying

Best antimicrobial peptide design software for a preclinical peptide program

The AMP toolchain splits into four jobs and most teams buy two tools that do the same one. Here is what each category actually returns, and which gap costs the most.

9 Sep 2026

Buying

Best antibacterial screening software for a small biotech discovery team

Most of the tools sold into discovery store your data or model your target. Very few answer the question an antibacterial program actually asks, which is compound against strain.

4 Aug 2026

Chemistry

Lead optimization in drug discovery, when the target is a bacterium

Standard lead optimization pushes lipophilicity up. For Gram-negatives that is often exactly the wrong direction, and the series dies on the plate.

28 Jul 2026

Screening

High content screening: when an image beats a growth curve

A growth curve tells you whether a compound worked. An image can tell you how, which is the more expensive question to answer later.

21 Jul 2026

Method

MIC in microbiology: how the number is actually measured

Broth microdilution, agar dilution and gradient strips give different answers for good reasons. Here is what happens on the bench, and where the error comes from.

14 Jul 2026

Method

Minimum inhibitory concentration definition: what a MIC actually tells you

The MIC is the lowest concentration that stops visible growth. That sentence hides a plate, a dilution series and a set of conventions worth knowing.