PBPK software license costs, from the public record

GastroPlus price: what a GastroPlus PBPK software license costs, from 31 federal awards

Simulations Plus publishes no price for GastroPlus. US federal procurement records are public, so here is what FDA, CDC, EPA and the Army actually signed for, alongside the antibacterial potency read-out that PBPK software does not give.

From $149 a month

31 federal awards name GastroPlus
Products kept apart from modules
No number we cannot source

The potency half of the PK and PD pair

of 3 left

Compound, by name or SMILES

Strain panel

S. aureus (MRSA) E. coli K. pneumoniae (CRE) A. baumannii P. aeruginosa E. faecium (VRE)

Read-out

Include closest published analogs

No account needed. 3 screens per session.

What comes back

Rows: One per strain in the panel
Per row: MIC band, S I R call, mechanism
Support: Confidence 1 to 4 and analogs
Typical run: About ten seconds

Sample output Ciprofloxacin Fluoroquinolone

Worked example, replaced when you run

Strain	MIC (µg/mL)	Call	Resistance risk
S. aureus (MRSA)	0.5->32	R Resistant	target mutation, grlA and gyrA Fluoroquinolone resistance is widespread in methicillin resistant lineages.
E. coli	<=0.015-0.06	S Susceptible	efflux, AcrAB-TolC in resistant isolates Potent against wild type; qnr carriage and gyrA changes shift the band sharply.
K. pneumoniae (CRE)	0.5->64	R Resistant	gyrA mutation with plasmid qnr Carbapenemase producing isolates almost always carry quinolone resistance too.
A. baumannii	8->64	R Resistant	efflux, AdeABC Constitutive efflux plus target changes leave little room at achievable exposure.
P. aeruginosa	0.25-2	I Intermediate	efflux, MexAB-OprM Borderline: active on many isolates, lost quickly once efflux is derepressed.
E. faecium (VRE)	4->32	R Resistant	target mutation, parC Enterococci are intrinsically poor fluoroquinolone targets.

Why

Ciprofloxacin is a well characterised fluoroquinolone, so the Gram-negative bands are strongly supported by published activity data. The deciding factor across this panel is not target affinity but exposure: efflux in P. aeruginosa and A. baumannii, and acquired target mutation everywhere resistance is already common. Against a modern ESKAPE panel it reads as a Gram-negative agent with two reliable losses.

Closest published analogs

Levofloxacin Broadly similar Gram-negative bands, better Gram-positive coverage
Delafloxacin Retains activity against many ciprofloxacin resistant staphylococci

Strain	MIC (µg/mL)	Call	Resistance risk	Conf.

Why

Closest published analogs

Want the rest of your series? Batch runs are on the paid tiers. screen left in this session. This session is used up.

Computational prediction from published literature. Research use only, not a lab measurement and not clinical guidance.

The short answer

What GastroPlus costs, in one paragraph

Simulations Plus does not publish a price for GastroPlus. The US federal award record does. The license that took effect in September 2026 covers GastroPlus and DDDPlus for twelve months at $79,812. The five year FDA term it succeeds covered GastroPlus, DDDPlus and MembranePlus for $375,965, an average near $75,200 a year. At the other end of the range, a CDC award for one user of ADMET Predictor and GastroPlus works out to about $19,400 a year, and a 2015 order covered 50 GastroPlus licenses plus 60 module licenses for $21,105. Government buyers order against schedule pricing, so treat every figure here as a floor for a commercial quote rather than a forecast.

One award is deliberately absent from the tables below. In 2018 the same vendor received $130,000 to extend and validate an ocular compartmental absorption and transit model. That is development work, not a license, and averaging it into a per year rate would overstate what the software costs.

Where the numbers come from

Every figure on this page is a signed US federal contract award, read from the public record at USAspending.gov, filtered to awards whose own description names GastroPlus. Thirty one awards qualify, from August 2008 to August 2027. Nothing here is an estimate, a survey or a figure repeated from another site.

Multi year totals are shown as the total and the term. Where we divide, the column says so.

Multi year terms

The long terms, and what they work out to a year

These are the awards that ran longer than a single year. The right hand column is simply the total divided by the term, which is useful for scale but is not necessarily how the license was billed. Option years, staged deliveries and mid term additions all break an even split.

Term	Agency	What the award covers	Total	Total over term
Aug 2021 to Aug 2026	FDA	GastroPlus, DDDPlus and MembranePlus software licenses	$375,965	about $75,200
Aug 2016 to Aug 2020	HHS	Purchase of GastroPlus licenses	$252,421	about $63,100
Feb 2020 to Mar 2025	Army	Annual renewal subscription, GastroPlus and ADMET, CCDC CBC	$160,321	about $32,100
Aug 2012 to Aug 2016	HHS	GastroPlus software	$120,540	$30,135
Feb 2021 to Jan 2026	CDC	Annual license, 1 user, ADMET Predictor and GastroPlus	$96,898	about $19,400
May 2024 to May 2027	EPA	ADMET Predictor and GastroPlus	$55,764	about $18,600
Apr 2021 to May 2024	EPA	GastroPlus with DDI, ADMET Predictor, Optimization, Metabolism and Transporter and PBPKPlus modules	$44,202	about $14,700

An exact multiple worth noticing

The 2012 to 2016 award totals $120,540 across four years, which is exactly four times the $30,135 that HHS paid in 2010 for ten GastroPlus 7.0 license agreements. The arithmetic is too clean to be coincidence: it reads as the same ten agreement package held at the same annual rate for four more years. If you are negotiating, that is evidence a multi year term can lock a rate rather than escalate it.

The spread is about products, not discounting

The table runs from about $14,700 a year to about $75,200, a five fold spread for the same named software. The difference is almost entirely what else is on the line. The top row covers three separate products; the bottom row covers GastroPlus with six modules at one agency. Read a quote by its line items, because the headline number tells you very little on its own.

Single terms and one time orders

The year by year prices, newest first

These awards each cover a stated period of roughly a year, or a single purchase, so no division is needed. The first row is the most useful number on this page, because it is current: it took effect in September 2026 and runs to August 2027.

Period	Agency	What the award covers	Amount
Sep 2026 to Aug 2027	HHS	GastroPlus and DDDPlus PBPK and PBBM platform licenses	$79,812
Aug 2021 to Aug 2022	Defense	GastroPlus software package, including modules	$46,620
Sep 2020	Defense	GastroPlus software license	$34,950
Sep 2019	Army, USAMRICD	GastroPlus software package, 1 year license	$17,135
Sep 2018	Defense	GastroPlus software package and 1 year license	$15,480
Sep 2015	HHS	50 GastroPlus licenses, 30 IVIVCPlus, 30 PBPKPlus	$21,105
May 2014	Defense	GastroPlus with the DDI module	$31,650
Sep 2010 to Sep 2011	HHS	Renewal package: GastroPlus, Optimization, IVIVCPlus, PKPlus	$30,600
Aug 2010 to Aug 2011	HHS	GastroPlus 7.0, ten license agreements	$30,135
Aug 2009 to Aug 2010	HHS	GastroPlus and program modules, ten license agreements	$20,090
Sep 2016 to Aug 2017	HHS	GastroPlus 9 license	$5,515
Aug 2009 to Aug 2010	HHS	Renewal, GastroPlus, all modules, DDDPlus	$7,650
Aug 2008 to Aug 2009	HHS	Renewal, GastroPlus and all modules, DDDPlus	$7,200

Four Septembers at the Department of Defense

Four consecutive September awards bought a GastroPlus package for defense laboratories. Read as a series they triple in three years. Read carefully, the scope wording changes between them, so this is not a clean repricing of one identical basket, and part of the jump is very likely more modules rather than a higher rate. It is still the closest thing in the record to a single buyer coming back every year, and it is worth knowing that direction of travel before a renewal call.

Sep 2018	$15,480	Software package and 1 year license
Sep 2019	$17,135	Up 10.7 percent, package for USAMRICD
Sep 2020	$34,950	Up 104 percent, described only as a license
Sep 2021	$46,620	Up 33.4 percent, package including modules

Base, modules and separate products

Which modules the government actually bought

Simulations Plus lists fourteen module extensions on its GastroPlus page. Seven of them are named explicitly in award descriptions, which tells you which parts of the platform working laboratories pay to add. The other seven may well be in those awards without being itemised, so an absence here means only that we could not read the name, not that nobody buys it.

The distinction that costs the most money is a different one. DDDPlus and MembranePlus are not modules. Neither appears in the vendor's own module list, because both are separate simulators, for in vitro dissolution and for membrane permeability. The largest award in the whole record covers all three products at once, which is why it is five times the size of a GastroPlus base license year.

ADMET Predictor Yes, repeatedly, and licensed on its own elsewhere

Drug Drug Interaction Yes, as the DDI module, twice

Optimization Yes, in 2010 and 2021

Metabolism and Transporter Yes, in the 2021 EPA award

PBPKPlus Yes, in 2015 and 2021

IVIVCPlus Yes, in 2010 and 2015

PKPlus Yes, in 2008 and 2010

Additional Dosage Routes Not named in any award we read

Biologics Not named in any award we read

AssessmentsPlus Not named in any award we read

Orchestrator Not named in any award we read

PDPlus Not named in any award we read

P-PSD Not named in any award we read

GastroPlusGPT Not named in any award we read

What moves your number

Four things that decide where a quote lands

How many products are on the line, not just how many modules

The largest award in the record covers three separate products: GastroPlus, DDDPlus and MembranePlus. Neither DDDPlus nor MembranePlus appears in the fourteen module extensions the vendor lists on its own GastroPlus page, because they are standalone simulators for dissolution and permeability. A quote that reads as one platform line can contain three products, so ask which of them you are actually buying.

Which of the fourteen modules you keep

The base engine covers mechanistic PBPK and PBBM modeling, human and animal physiologies, the absorption models, a DDI framework, population simulation and reporting. Everything past that is a module, and award descriptions name DDI, Optimization, Metabolism and Transporter, PBPKPlus, IVIVCPlus, PKPlus and ADMET Predictor by name. The EPA award that lists six modules at once cost roughly $14,700 a year; a single module attached to a base license in 2014 cost $31,650 on its own order.

Seats, and whether the license floats

Licenses are managed through a cloud license server or on demand activation, in standalone or floating form. The cleanest per seat number in the public record is a CDC award for one user of ADMET Predictor and GastroPlus at about $19,400 a year. At the other end, an HHS order in 2010 bought ten license agreements for $30,135, close to $3,000 each, and a 2015 order covered 50 GastroPlus licenses plus 60 module licenses for $21,105. Volume moves this price more than almost anything else.

Academic, government or commercial price sheet

Simulations Plus runs a University+ academic route through a request form, and government buyers order against schedule pricing. Neither is the commercial sheet. Treat every figure on this page as a floor for a company quote rather than a forecast, because the same software reaches a biotech through a different catalogue.

Where this tool fits, and where it does not

PBPK gives you exposure. It does not give you potency.

Buy GastroPlus when the question is exposure

If you need to know how much drug reaches plasma, tissue or the site of infection, for how long, under what formulation, in which population, and how a co administered drug changes it, that is what a mechanistic PBPK and PBBM engine is for. Nothing on this site replaces it. The vendor has been building those physiologies for two decades and regulators use the output.

It is also the right purchase when the deliverable is a regulatory submission, a biowaiver argument or a formulation decision. Those are exposure questions end to end.

You still need the other number

An antibacterial efficacy argument is a ratio. The standard indices are the fraction of the dosing interval spent above the MIC, the area under the curve divided by the MIC, and peak concentration divided by the MIC. PBPK software supplies the numerator with real rigour. Every one of those indices has the MIC in the denominator, and GastroPlus does not predict it.

That ordering matters for a budget. Modeling the exposure of a compound that inhibits nothing is wasted work, and the potency read-out is by far the cheaper half to obtain. A pre-trained antibacterial model returns a predicted MIC band per organism across a 6 strain ESKAPE panel in about ten seconds, with the mechanism class and the closest published analogs, for a monthly fee rather than an annual license.

Who reads this page

Six reasons people look this number up

You are budgeting a PBPK seat

Put a signed figure in the grant or the board deck before the quote arrives, and know whether it covers one product or three.

You are facing a renewal

Hold the increase against a 12 month platform license at $79,812 and a five year term that averaged about $75,200 a year.

You are comparing GastroPlus with Simcyp

Read both from the same kind of evidence rather than one vendor page against another.

You are unbundling a quote

Separate GastroPlus from DDDPlus, MembranePlus and ADMET Predictor so two quotes compare on the same basis.

You work on antibacterials

Exposure modeling needs a MIC to be worth anything, and the MIC is the cheaper half of that pair to obtain.

Your first question is potency

If you do not yet know which compounds inhibit which organisms, a PBPK license answers the second question before the first.

Questions people ask before buying

GastroPlus pricing, answered plainly

How much does GastroPlus cost?

Simulations Plus publishes no price. Public US federal awards show what agencies paid: a 12 month license covering GastroPlus and DDDPlus took effect in September 2026 at $79,812, a five year FDA term covering GastroPlus, DDDPlus and MembranePlus came to $375,965, and a single user award covering ADMET Predictor and GastroPlus works out near $19,400 a year. Commercial quotes come off a different price sheet.

Does Simulations Plus publish GastroPlus pricing?

No. The GastroPlus product page describes the modeling engine, the physiologies, the absorption models and fourteen module extensions, then routes buyers to a demo or a quote. It states no price, no tier and no per seat rate. The only public numbers come from procurement records, where agencies disclose what they signed for licenses and renewals.

How much is a single user GastroPlus license?

The clearest single user figure in the public record is a CDC award covering one user of ADMET Predictor and GastroPlus for five years at $96,898, which works out to about $19,400 a year for both products together. Older HHS orders bought licenses in blocks instead, ten agreements for $30,135 in 2010, so roughly $3,000 each at that time.

Is DDDPlus included in a GastroPlus license?

Not automatically. DDDPlus is a separate dissolution simulator and does not appear among the fourteen module extensions the vendor lists for GastroPlus. Several federal awards license the two together, and the largest adds MembranePlus as a third product, which is why a single platform line in a quote can hide three purchases. Ask for each product on its own line.

Did GastroPlus renewals go up or down?

Up, on the clearest succession in the record. A five year FDA term for GastroPlus, DDDPlus and MembranePlus totalled $375,965, an average near $75,200 a year, and the award that starts the day after that term ends covers GastroPlus and DDDPlus for twelve months at $79,812. That is about 6 percent above the earlier average for one product fewer.

What does GastroPlus actually predict?

Exposure. The vendor describes a mechanistic PBPK and PBBM engine with human and animal physiologies, absorption and biopharmaceutics models, a drug interaction framework and population simulation. It models where a compound goes, at what concentration and for how long. It does not tell you what concentration inhibits a given bacterium, so potency comes from somewhere else.

Do I need GastroPlus to screen antibacterial compounds?

Not for the first question. An antibacterial efficacy argument is built on exposure measured against the MIC, using indices such as the fraction of the dosing interval above MIC, or AUC divided by MIC. GastroPlus supplies the exposure half. Without a MIC per organism, those ratios have no denominator, and modeling the exposure of a compound that inhibits nothing is wasted work.

Is GastroPlus cheaper than Simcyp?

They overlap heavily in the public record. Certara Simcyp awards include a single node annual license at $10,500 rising to $11,686 across three years, and departmental FDA renewals flat at $65,000 a year for three consecutive years. GastroPlus platform awards run higher at the top, near $75,000 to $80,000 a year, but those cover several products. Configurations differ, so compare what is on each line rather than the headline.

Pricing

Published, monthly, and on this page

Full plan comparison

Lab is $149 a month for 250 screens with batches up to 50 compounds, which is $1,788 across a year. Discovery is $499 for 2,000 screens, batches up to 1,000, and adds the API. Program is $1,490 for 10,000 screens with batches up to 10,000. The 12 month platform license that took effect in September 2026 would pay for 44 years of Lab, and the CDC single user rate for 10 years. That is a fair comparison only when the potency answer is the one you need first.

Yearly billing is two months cheaper, charged once a year.

Lab

$124 /mo

$1,488 charged once a year

250 screens a month against the standard panels, with CSV export.

Get started

Academic AMR lab, 1 to 2 chemists

Discovery

Get the MIC before you model the exposure

Paste a compound you already know the MIC for, read the panel, then decide which compounds are worth a PBPK run.

Run a screen first

What you are agreeing to

Your compounds stay yours
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