ADMET software license costs, from the public record

ADMET Predictor price: what a Simulations Plus ADMET Predictor license costs, from 14 federal awards

Simulations Plus publishes no price for ADMET Predictor. US federal procurement records are public, so here is what FDA, CDC, EPA and NIH actually paid, alongside the antibacterial potency read-out that ADMET software does not give.

From $149 a month

14 federal awards name ADMET
GastroPlus bundles kept apart
No number we cannot source

The potency answer ADMET software does not give

of 3 left

Compound, by name or SMILES

Strain panel

S. aureus (MRSA) E. coli K. pneumoniae (CRE) A. baumannii P. aeruginosa E. faecium (VRE)

Read-out

Include closest published analogs

No account needed. 3 screens per session.

What comes back

Rows: One per strain in the panel
Per row: MIC band, S I R call, mechanism
Support: Confidence 1 to 4 and analogs
Typical run: About ten seconds

Sample output Ciprofloxacin Fluoroquinolone

Worked example, replaced when you run

Strain	MIC (µg/mL)	Call	Resistance risk
S. aureus (MRSA)	0.5->32	R Resistant	target mutation, grlA and gyrA Fluoroquinolone resistance is widespread in methicillin resistant lineages.
E. coli	<=0.015-0.06	S Susceptible	efflux, AcrAB-TolC in resistant isolates Potent against wild type; qnr carriage and gyrA changes shift the band sharply.
K. pneumoniae (CRE)	0.5->64	R Resistant	gyrA mutation with plasmid qnr Carbapenemase producing isolates almost always carry quinolone resistance too.
A. baumannii	8->64	R Resistant	efflux, AdeABC Constitutive efflux plus target changes leave little room at achievable exposure.
P. aeruginosa	0.25-2	I Intermediate	efflux, MexAB-OprM Borderline: active on many isolates, lost quickly once efflux is derepressed.
E. faecium (VRE)	4->32	R Resistant	target mutation, parC Enterococci are intrinsically poor fluoroquinolone targets.

Why

Ciprofloxacin is a well characterised fluoroquinolone, so the Gram-negative bands are strongly supported by published activity data. The deciding factor across this panel is not target affinity but exposure: efflux in P. aeruginosa and A. baumannii, and acquired target mutation everywhere resistance is already common. Against a modern ESKAPE panel it reads as a Gram-negative agent with two reliable losses.

Closest published analogs

Levofloxacin Broadly similar Gram-negative bands, better Gram-positive coverage
Delafloxacin Retains activity against many ciprofloxacin resistant staphylococci

Strain	MIC (µg/mL)	Call	Resistance risk	Conf.

Why

Closest published analogs

Want the rest of your series? Batch runs are on the paid tiers. screen left in this session. This session is used up.

Computational prediction from published literature. Research use only, not a lab measurement and not clinical guidance.

The short answer

About $19,000 to $20,000 a year per seat on long terms, less on one year renewals

Simulations Plus does not publish a price for ADMET Predictor. US federal agencies have been buying it since at least 2012, though, and those awards are public. Fifty one contract awards to Simulations Plus appear in the federal spending record between 2008 and 2026, worth about $2.2 million in total, and fourteen of them name ADMET Predictor, or the ADMET software, in their own description.

The long terms are the clearest signal. FDA paid $100,337 for five years of ADMET Predictor license renewals and support from 2021 to 2026, about $20,000 a year. CDC paid $96,898 over the same period for one user of ADMET Predictor and GastroPlus, about $19,400 a year. EPA's current three year term for both products is $55,764, about $18,600 a year. One year awards are smaller, from $3,411 to $18,900, and the most recent, for the FDA Office of Cosmetics and Colors in August 2026, is $12,848.

One caveat governs every number here. These are government purchases, and a commercial biotech is quoted from a different sheet. Read the tables as a floor and a shape, not a forecast of your quote.

At a glance

Published price: None, Simulations Plus quotes on request
Public evidence: 51 US federal awards, 2008 to 2026, 14 name ADMET
Per seat, long term: About $19,000 to $20,000 a year
Priced here: $149 to $1,490 a month, on the page, no quote cycle

What agencies actually paid

ADMET Predictor license cost over multi year terms

These awards run two to five years, so the last column is the total divided by the term. It is shown for scale and is not an annual price anyone was quoted. Descriptions are shortened from the award record.

Term	Agency	What it covers	Award total	Per year, for scale
Feb 2021 to Feb 2026	FDA	ADMET Predictor license renewals and support	$100,337	about $20,000
Feb 2021 to Jan 2026	CDC	Annual license, 1 user, ADMET Predictor and GastroPlus	$96,898	about $19,400
May 2024 to May 2027	EPA	ADMET Predictor and GastroPlus	$55,764	about $18,600
Apr 2021 to May 2024	EPA	GastroPlus with its ADMET Predictor module and others	$44,202	about $14,700
Feb 2020 to Mar 2025	Army	Annual renewal subscription, GastroPlus and ADMET	$160,321	about $32,000
Jan 2019 to Jan 2021	FDA	ADMET Predictor software	$33,253	about $16,600

Source: public US federal contract awards to Simulations Plus, Inc. Awards to an unrelated assistive technology vendor with a similar name are excluded.

Why three agencies land on nearly the same number

FDA, CDC and EPA bought different configurations on different dates, and still ended up between $18,600 and $20,000 a year. That clustering is the most useful thing on this page. It suggests a list price for a single ADMET Predictor seat, with or without a GastroPlus seat alongside it, sitting in that band for government buyers across 2021 to 2027. The Army outlier at about $32,000 a year describes a subscription to both products for a whole research directorate, so it is the wider configuration, not a higher rate.

One year at a time

One year ADMET Predictor awards, and a renewal that fell 30 percent

Start	Agency	What it covers	Amount
Aug 2026	FDA, Office of Cosmetics and Colors	ADMET Predictor	$12,848
Nov 2019	CDC	License renewal, ADMET Predictor and GastroPlus modules	$10,660
Sep 2016	CDC	ADMET Predictor license	$4,500
Jun 2015	EPA	GastroPlus and ADMET Predictor renewal	$3,411
Aug 2014	NIH	Renewal: GastroPlus, ADMET Predictor, MedChem Studio	$13,230
Jun 2014	EPA	GastroPlus and ADMET Predictor licenses	$6,640
Aug 2013	NIH	Renewal: GastroPlus, ADMET Predictor, MedChem Studio	$15,120
Aug 2012	NIH	Renewal: GastroPlus, ADMET Predictor, MedChem Studio	$18,900

The smallest figures, $3,411 and $4,500, are renewals or single add-on licenses rather than a first year of a full seat, so do not budget from them. The August 2026 FDA award matches a September 2026 Simulations Plus announcement that the FDA cosmetics branch had licensed ADMET Predictor. The announcement gave no amount; the award record does.

NIH annual renewal, same office

2011	$18,900	Products not named
2012	$18,900	Flat
2013	$15,120	Down 20.0 percent
2014	$13,230	Down 12.5 percent

From 2012 each award names GastroPlus, ADMET Predictor and MedChem Studio. A later NIH series for one named user of Simulations Plus software also fell, from $12,107 in 2015 and 2016 to $10,707 in 2017.

What moves your number

Four things decide where a Simulations Plus quote lands

01

ADMET Predictor alone, or with GastroPlus

Most federal buyers license ADMET Predictor together with GastroPlus, the Simulations Plus PBPK simulator, and the two are often priced as one line. GastroPlus is the heavier product: FDA paid $375,965 over five years for GastroPlus, DDDPlus and MembranePlus. If you only need property predictions, say so before the quote is drafted, because a bundle is easy to propose and hard to unpick.

02

Which modules sit on top of the base

Simulations Plus lists ADMET Modeler, AI-Driven Drug Design, HTPK Simulation, Metabolism, Toxicity, Transporters, a physicochemical and biopharmaceutical module, DILIsym inputs, MedChem Studio and additional dosage routes. The base predicts the property set; the modules add model building, generative design and deeper metabolism and toxicity work. Each one moves the number.

03

Seats and license type

The vendor supports standalone and floating licenses, managed through a cloud license server or on demand activation. A floating license shared by a small team costs more than one named seat but less than a seat each. The clearest per seat figure on the public record is a CDC award for one user of ADMET Predictor and GastroPlus at about $19,400 a year.

04

Desktop, REST API or a pipeline

ADMET Predictor runs as a desktop application, through a REST API, as KNIME components, inside Pipeline Pilot, and inside third party platforms such as Certara D360 and Schrodinger LiveDesign. Running it as a service behind other software is a different license from one scientist at a desk. Ask for the API terms in writing if you plan to call it from code.

Honest comparison

When ADMET Predictor is the right buy, and when the first question is potency

Buy ADMET Predictor when

You already have active compounds and need to know which will survive absorption, metabolism and toxicity.
You want a large library of shipped property models without collecting training data first.
You plan to build your own ADMET models on in house data, which is what ADMET Modeler is for.
PBPK is on the roadmap, and licensing it next to GastroPlus keeps one vendor for both.
Someone on the team runs property profiling every week and will keep the seat busy.

Price a potency read-out first when

You do not yet know which compounds inhibit which organisms, so there is nothing to profile.
The deciding question is whole cell activity through a Gram-negative envelope, which ADMET models do not score.
The budget is a grant line that cannot absorb a five figure annual seat on top of assays.
You want to cut a purchased library before any plate is poured.
You need an answer this week, not after a demo, a quote and a purchase order.

This site is not an ADMET Predictor replacement, and it would be dishonest to sell it as one. ADMET Predictor covers more than 175 properties we do not attempt. The two tools answer questions in a fixed order, though. An antibacterial program first has to find compounds that inhibit Klebsiella pneumoniae or Acinetobacter baumannii at a useful concentration, and only then asks whether they will behave as drugs. Paste a structure or a peptide sequence here, and a predicted MIC band comes back for each organism in a 6 strain panel, with an S, I or R call, the resistance mechanism expected to limit it, and a confidence level on every row. The compounds that pass are the ones worth an ADMET seat.

If you are comparing property and modeling suites rather than deciding what to buy first, see StarDrop pricing, which covers the closest ADMET competitor and the only one that publishes a range, and QSAR software for antibacterial activity, which compares ADMET Modeler with the other model builders. The category wide view is on drug discovery software cost, and the same public record prices MOE and OpenEye.

Who this page is for

Six moments when the ADMET Predictor price matters

You are budgeting an ADMET seat

Put a sourced figure in the grant or the board deck before the quote arrives, and know whether it includes GastroPlus.

You are facing a renewal

Hold the increase up against an NIH renewal that fell 30 percent over three years and a five year FDA term near $20,000 a year.

You are choosing between bundles

See why ADMET Predictor with GastroPlus is priced as a different order of spend from ADMET Predictor alone.

You plan to call it from code

Separate a desktop seat from REST API or pipeline use so two quotes compare on the same basis.

You are shortlisting vendors

Read this next to StarDrop, MOE and Schrodinger, all priced from the same kind of evidence.

Your first question is potency

If you do not yet know which compounds inhibit which organisms, an ADMET license answers the second question before the first.

Questions people ask before buying

ADMET Predictor pricing, answered plainly

How much does ADMET Predictor cost?

Simulations Plus publishes no price, but US federal award records show what agencies paid. One year awards naming ADMET Predictor run from $3,411 to $18,900. Five year terms work out to about $19,400 to $20,000 a year, including a CDC award for one user of ADMET Predictor and GastroPlus. Commercial quotes start from a different price sheet.

Does Simulations Plus publish pricing for ADMET Predictor?

No. The ADMET Predictor product page describes the models, modules and deployment options and routes buyers to a demo or a quote. It lists no price, no tier and no per seat rate. The only public numbers come from procurement records, where government agencies disclose what they paid for licenses, renewals and support.

What does ADMET Predictor predict?

Simulations Plus states that ADMET Predictor covers more than 175 properties across physicochemical, ADME, toxicity and pharmacokinetic endpoints, such as solubility, permeability, metabolism, transporter interactions and toxicity alerts. It does not predict antibacterial potency against a specific organism, so a MIC per strain needs a different model or a lab assay.

Is ADMET Predictor sold with GastroPlus?

Often, but not necessarily. Many federal awards license ADMET Predictor and GastroPlus together, and some list ADMET Predictor as a GastroPlus module. Others, such as the FDA award for ADMET Predictor license renewals and support, cover ADMET Predictor alone. GastroPlus is the more expensive product, so a quote that bundles both should be read line by line.

Did ADMET Predictor renewals go up or down?

On the one clean series in the record, they went down. The same NIH office renewed GastroPlus, ADMET Predictor and MedChem Studio at $18,900 in 2012, $15,120 in 2013 and $13,230 in 2014, a fall of 30 percent in two years. A renewal is a negotiation, and the public record shows it moving in the buyer's favor.

Can ADMET Predictor be used through an API?

Yes. Simulations Plus lists a REST API, KNIME components and a Pipeline Pilot integration alongside the desktop application, and ADMET Predictor also runs inside platforms such as Certara D360 and Schrodinger LiveDesign. API or server use is usually licensed differently from a desktop seat, so ask for those terms explicitly.

Is ADMET Predictor cheaper than StarDrop or Schrodinger?

On the evidence available, it sits at the lower end. Federal awards put ADMET Predictor near $19,000 to $20,000 a year per seat over long terms. Optibrium says StarDrop starts at around $10,000 a year and rises into six figures with modules. Schrodinger small molecule suite awards run about $194,000 to $206,000 a year. Scopes differ, so compare configurations.

Do I need ADMET Predictor to screen compounds for antibacterial activity?

Not for the first question. ADMET Predictor tells you whether a compound behaves like a drug: absorption, metabolism, toxicity. It does not tell you whether the compound inhibits Pseudomonas or Klebsiella. A pre-trained antibacterial read-out returns a predicted MIC band per organism in about ten seconds, at a monthly price, and ADMET work follows on the compounds that pass.

Pricing

Published, monthly, and on this page

Full plan comparison

Lab is $149 a month for 250 screens with batches up to 50 compounds, which is $1,788 across a year. Discovery is $499 for 2,000 screens, batches up to 1,000, and adds the API. Program is $1,490 for 10,000 screens with batches up to 10,000. The CDC one user rate for ADMET Predictor and GastroPlus would pay for 10 years of Lab, which is a fair comparison only when the potency answer is the one you need first.

Yearly billing is two months cheaper, charged once a year.

Lab

$124 /mo

$1,488 charged once a year

250 screens a month against the standard panels, with CSV export.

Get started

Academic AMR lab, 1 to 2 chemists

Discovery

Find the actives before you price the ADMET seat

Paste a compound you already know the MIC for, read the panel, then decide which compounds deserve property profiling.

Run a screen first

What you are agreeing to

Your compounds stay yours
Never used for model training
Deletable on request
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