PK software license costs, from the public record
Phoenix WinNonlin price, WinNonlin license cost and Certara Phoenix pricing, from 42 federal awards
Certara publishes no price for Phoenix WinNonlin. US federal procurement records are public, so here is what FDA, NIH and the Army actually paid per seat and per platform, alongside the antibacterial potency read-out that PK software does not give.
- 42 federal awards name WinNonlin or Phoenix
- Floating and named seats kept apart
- No number we cannot source
The MIC your AUC target divides by
of 3 left
Strain panel
No account needed. 3 screens per session.
| Strain | MIC (µg/mL) | Call | Resistance risk | Conf. |
|---|---|---|---|---|
| S. aureus (MRSA) | 0.5->32 | R Resistant | target mutation, grlA and gyrA Fluoroquinolone resistance is widespread in methicillin resistant lineages. | |
| E. coli | <=0.015-0.06 | S Susceptible | efflux, AcrAB-TolC in resistant isolates Potent against wild type; qnr carriage and gyrA changes shift the band sharply. | |
| K. pneumoniae (CRE) | 0.5->64 | R Resistant | gyrA mutation with plasmid qnr Carbapenemase producing isolates almost always carry quinolone resistance too. | |
| A. baumannii | 8->64 | R Resistant | efflux, AdeABC Constitutive efflux plus target changes leave little room at achievable exposure. | |
| P. aeruginosa | 0.25-2 | I Intermediate | efflux, MexAB-OprM Borderline: active on many isolates, lost quickly once efflux is derepressed. | |
| E. faecium (VRE) | 4->32 | R Resistant | target mutation, parC Enterococci are intrinsically poor fluoroquinolone targets. |
Why
Ciprofloxacin is a well characterised fluoroquinolone, so the Gram-negative bands are strongly supported by published activity data. The deciding factor across this panel is not target affinity but exposure: efflux in P. aeruginosa and A. baumannii, and acquired target mutation everywhere resistance is already common. Against a modern ESKAPE panel it reads as a Gram-negative agent with two reliable losses.
Closest published analogs
- Levofloxacin Broadly similar Gram-negative bands, better Gram-positive coverage
- Delafloxacin Retains activity against many ciprofloxacin resistant staphylococci
| Strain | MIC (µg/mL) | Call | Resistance risk | Conf. |
|---|---|---|---|---|
Why
Closest published analogs
Want the rest of your series? Batch runs are on the paid tiers. screen left in this session. This session is used up.
Computational prediction from published literature. Research use only, not a lab measurement and not clinical guidance.
The short answer
What Phoenix WinNonlin costs, in one paragraph
Certara does not publish a price for Phoenix WinNonlin. The US federal award record does. One annual named user license cost $5,870 in 2016 and $6,400 in 2018, and a two seat annual award in 2024 came to $17,556, about $8,778 per seat. At enterprise scale the FDA's current agreement for a combination of Phoenix licenses runs $665,980 across four years, about $166,500 a year. Government buyers order against schedule pricing, so treat every figure here as a floor for a commercial quote rather than a forecast.
Where the numbers come from
Every figure is a signed US federal contract award, read from the public record at USAspending.gov and filtered to awards whose own description names WinNonlin or Phoenix. Forty two qualify, from December 2007 to July 2027, written to Certara USA and to Pharsight, the company that built WinNonlin and is now part of Certara. Two awards are left out: a 2015 Pharsight order with no description at all, and a 2011 training course recorded at zero dollars.
One seat, one year, sixteen years
What a single WinNonlin seat cost, from 2008 to 2024
Each bar is the cost of one seat for one year as the award states it. The early bars are floating seats, the six user FDA license divided by six. The 2016 and 2018 bars are single named user licenses. The 2024 bar is a two seat NIH award divided by two. A floating seat is shared, so it is not the same product as a named seat, and the colors keep them apart.
The same price at two agencies
NIH bought an annual named user license, product code PHXWNL088, for $5,870 in July 2016. Two months later the Army recorded an award for exactly $5,870, described only as a subscription. Two unrelated buyers landing on the identical figure in the same season is what a list price looks like from the outside, and it is the best evidence available of the 2016 single seat rate.
About 5 percent a year since then
From $5,870 in 2016 to about $8,778 per seat in 2024 is a rise of roughly 50 percent, close to 5 percent a year compounded. The step from 2016 to 2018 alone was 9 percent. If a renewal proposes well above that pace, this series is a signed, vendor specific comparison to put in the reply, rather than a market average.
A renewal series
Six floating licenses, renewed every August 25
These awards cover what is plainly one continuing agreement at the FDA: a six user floating WinNonlin license, every term ending on August 25. The first award is recorded as a ratified procurement, meaning the license was used before the paperwork caught up, which is common with a tool a review team cannot work without. The 2012 renewal is flagged as a critical function and its amount is not in the record.
| Term | How the award describes it | Amount | Change |
|---|---|---|---|
| Aug 2008 to Aug 2009 | WinNonlin Pro, floating, 6 users (recorded as a ratified procurement) | $12,780 | Baseline |
| Aug 2009 to Aug 2010 | WinNonlin Pro, floating, 6 users | $13,410 | Up 4.9 percent |
| Aug 2010 to Aug 2011 | WinNonlin software renewal | $14,754 | Up 10.0 percent |
| Aug 2011 to Aug 2012 | Renewal of 6 licenses for WinNonlin software | $26,600 | Up 80.3 percent |
| Aug 2012 to Aug 2013 | Renewal of the 6 floating licenses plus one WinNonlin and one NLME node | Not recorded | Amount not in the record |
| Jul 2013 to Aug 2014 | 6 WinNonlin professional licenses | $22,101 | Down 16.9 percent on 2011 |
Two lessons sit in that table. Renewals crept up 5 then 10 percent, then jumped 80 percent in one year with the seat count unchanged; the award does not say why, so ask about any renewal that moves that far. And two years later the same six seats cost 17 percent less. A renewal price is a negotiated number, and it can move down as well as up.
Enterprise and server terms
Certara Phoenix at the FDA, from desktop bundle to Quantum server
The FDA's platform agreement renews every July. The right hand column is the total divided by the term, useful for scale but not necessarily how the agreement was billed.
| Term | Buyer | What the award covers | Total | Total over term |
|---|---|---|---|---|
| Jul 2023 to Jul 2027 | FDA, CDER | Certara Phoenix licenses combination | $665,980 | about $166,500 |
| Jul 2020 to Jul 2023 | FDA | Certara Phoenix license subscription | $216,548 | about $72,200 |
| Jul 2019 to Jul 2022 | FDA | Annual named user server licenses of Phoenix WinNonlin, Phoenix Connect and Phoenix NLME, plus an unlimited server license | $169,505 | about $56,500 |
| Jul 2018 to Jul 2019 | FDA, CDER and CTP | Phoenix Quantum annual server licenses and maintenance | $151,470 | $151,470 |
| Jul 2016 to Jul 2017 | FDA | Phoenix Quantum software bundle | $153,470 | $153,470 |
| Jul 2014 to Jul 2015 | FDA | Pharsight desktop software bundle, license and maintenance | $57,698 | $57,698 |
| Jul 2013 to Jul 2014 | FDA | Pharsight desktop software bundle license | $54,950 | $54,950 |
Flat for three years, then a step
A single year of Phoenix Quantum cost the FDA $153,470 in 2016 and $151,470 in 2018, essentially flat. The 2020 subscription averaged about $72,200 a year over three years, and the award that starts the day after it ends, in July 2023, averages about $166,500 a year over four. That last step is 2.3 times the previous rate, and the description changed from a subscription to a combination of licenses, so part of it is almost certainly scope. Ask what a combination contains before you compare.
Desktop bundle, 5 percent a year
Before the server era the FDA bought a Pharsight desktop bundle: $54,950 for the year from July 2013 and $57,697.95 for the year from July 2014, up 5.0 percent. That matches the pace the named user seat shows later, which suggests roughly 5 percent is where Certara pitches a routine renewal.
Seats, nodes and single products
Smaller WinNonlin and Phoenix orders, newest first
These are the orders closest to what a small biotech or a single PK scientist buys. Each covers about a year or a single purchase, so no division is needed. Where the description does not state a seat count, we have not guessed one.
| Period | Buyer | What the award covers | Amount |
|---|---|---|---|
| Dec 2024 to Dec 2025 | NIH | Phoenix and Pirana software licenses | $16,441 |
| Jul 2024 to Jul 2025 | NIH | Phoenix WinNonlin annual software, quantity 2 | $17,556 |
| Jun 2024 to May 2025 | NIH | Phoenix WinNonlin software | $19,950 |
| May 2024 to May 2025 | NIH | Phoenix WinNonlin 2023 software | $12,266 |
| May 2023 to May 2024 | NIH | Phoenix WinNonlin | $15,422 |
| Sep 2020 to Sep 2021 | NIH | Phoenix WinNonlin and Phoenix NLME annual named user licenses | $11,218 |
| Jun 2019 to Jul 2020 | FDA | Phoenix, IVIVC Toolkit for Phoenix WinNonlin and Trial Simulator | $68,019 |
| Sep 2018 | Army | WinNonlin license | $31,425 |
| Jul 2018 to Jul 2019 | NIH | Annual named user license | $6,400 |
| Jul 2016 to Aug 2016 | NIH | Phoenix WinNonlin annual named user license | $5,870 |
| Feb 2014 to Feb 2015 | FDA | Phoenix WinNonlin annual node license | $5,635 |
| Feb 2014 to Jan 2015 | NIH | Phoenix NLME annual node license, new | $6,620 |
| May 2012 | Army | Phoenix NLME node, annual | $10,832 |
| Jul 2012 to Aug 2012 | FDA | Renewal of 2 WinNonlin Pro node licenses | $3,792 |
| 2008 | Army and USUHS | WinNonlin Pro node, initial, one award each | $4,750 |
What moves your number
Four things that decide where a Phoenix quote lands
Named user, floating or node
The award descriptions record a change of license model. Before 2015 they speak of floating licenses and node licenses; from 2016 onward they speak of annual named user licenses. A floating seat is shared by whoever is logged in, a named user seat belongs to one person, and the two are not priced the same way. When you compare an old invoice with a new quote, compare seats of the same kind.
Which Phoenix products are on the line
WinNonlin is the noncompartmental and PK/PD engine. Phoenix NLME, Phoenix Connect, the IVIVC Toolkit, Trial Simulator and Pirana are separate items, and every one of them appears by name in a federal award. A 2020 NIH order for one WinNonlin and one NLME named user seat came to $11,218, which is why a Phoenix quote should always be read line by line.
Desktop or server
Phoenix Quantum is the server deployment. The FDA paid $151,470 for a single year of Quantum server licenses and maintenance in 2018, and a three year award for named user server licenses plus an unlimited server license averaged about $56,500 a year. Server deployments trade a higher entry price for central administration and validation, which is what a regulated group is usually buying.
Academic, government or commercial price sheet
Certara states that it gives free Phoenix desktop licenses for teaching an academic course, plus free Pirana and RsNLME licenses for academic use. Government buyers order against schedule pricing. Neither is the commercial sheet, so treat every figure on this page as a floor for a company quote rather than a forecast.
Where this tool fits, and where it does not
WinNonlin gives you the AUC. It does not give you the MIC.
Buy Phoenix WinNonlin when the question is exposure
Noncompartmental analysis, bioequivalence, toxicokinetics, dose proportionality and PK/PD model fitting from measured concentrations are what WinNonlin is for, and it has been the reference tool for that work for three decades. Certara lists the FDA, PMDA and MHRA among the regulators that use the platform. If your deliverable is a study report or a submission table, nothing on this site replaces it.
You still need the other number
Antibacterial dose selection runs on ratios: free drug AUC over MIC, time above MIC, peak over MIC. WinNonlin computes the exposure half from your concentration data. Every one of those targets has the MIC in the denominator, and WinNonlin does not predict it. Measuring exposure for a compound that inhibits nothing is wasted study budget.
The potency read-out is the cheaper half to get first. A pre-trained antibacterial model returns a predicted MIC band per organism across a 6 strain ESKAPE panel in about ten seconds, with the mechanism class and the closest published analogs, for a monthly fee rather than an annual license.
Who reads this page
Six reasons people look this number up
You are budgeting a PK seat
Put a signed per seat figure in the grant or the plan before the quote arrives, and know whether it is floating or named.
You are facing a renewal
Hold the increase against a named user seat that went from $5,870 in 2016 to about $8,778 per seat in 2024.
You are moving to Phoenix Quantum
See what a server deployment cost the FDA a year, before and after it became a multi year agreement.
You are unbundling a quote
Separate WinNonlin from NLME, Connect, the IVIVC Toolkit and Trial Simulator so two quotes compare on the same basis.
You work on antibacterials
An AUC over MIC target needs a MIC, and the MIC is the cheaper half of that pair to obtain.
Your first question is potency
If you do not yet know which compounds inhibit which organisms, a PK license answers the second question before the first.
Phoenix is not the only Certara product with a public price trail. The Simcyp Simulator price record shows a node license repriced three years running, contracted through Certara UK rather than Certara USA. For exposure prediction before any animal data exists, the GastroPlus price breakdown covers the competing PBPK platform, and the drug discovery software cost pillar puts all of these side by side.
Questions people ask before buying
WinNonlin pricing, answered plainly
How much does Phoenix WinNonlin cost?
Certara publishes no price. Public US federal awards show what agencies paid: a single annual named user license at $5,870 in 2016 and $6,400 in 2018, a two seat annual award at $17,556 in 2024, or about $8,778 per seat, and enterprise Phoenix agreements at the FDA from about $56,500 to $166,500 a year. Commercial quotes come off a different price sheet.
How much is a WinNonlin license?
For one person for one year, the cleanest public figures are NIH awards for an annual named user license: $5,870 in July 2016 and $6,400 in July 2018. An Army award in September 2016 came to exactly $5,870 as well, described only as a subscription. The most recent per seat figure, from a 2024 two seat award, is about $8,778.
What is the difference between a named user and a floating WinNonlin license?
A floating license is a pool of seats shared by whoever is using the software at the moment; a named user license belongs to one named person. The federal record shows the shift: awards before 2015 describe floating and node licenses, and awards from 2016 describe annual named user licenses. The FDA paid about $2,100 to $4,400 per floating seat a year between 2008 and 2013.
How much does Phoenix NLME cost?
Phoenix NLME is licensed separately from WinNonlin. Public awards include an annual NLME node license at $6,620 (NIH, 2014), an NLME node at $10,832 (Army, 2012) and an FDA order for NLME licenses at $20,286 (2014). A 2020 NIH award for one WinNonlin and one NLME named user seat together came to $11,218.
Did WinNonlin prices go up?
Yes, on the per seat figures. A named user seat went from $5,870 in 2016 to $6,400 in 2018, up 9 percent, and a 2024 two seat award works out near $8,778 per seat, roughly 50 percent above 2016 or about 5 percent a year. Earlier, an FDA floating license rose 80 percent in one renewal in 2011, then fell 17 percent two years later.
What does a Phoenix Quantum server license cover?
Quantum is the server deployment of the Phoenix platform. The FDA award descriptions name annual server licenses and maintenance, and in one case annual named user server licenses of Phoenix WinNonlin, Phoenix Connect and Phoenix NLME together with an unlimited server license for distributed computing. That three year award came to $169,505, about $56,500 a year.
Does Certara offer an academic WinNonlin license?
Certara states on its Phoenix WinNonlin page that it gives free Phoenix desktop licenses when you teach an academic course, and free Pirana and RsNLME licenses for academic use, with discounts on other Phoenix products, training and certification. A research group that is not teaching a course should expect a discounted academic quote rather than a free license.
Does WinNonlin calculate AUC over MIC for antibiotics?
WinNonlin calculates the exposure side, including AUC, Cmax and time above a threshold, from concentration data. The pharmacodynamic indices used for antibiotics, such as AUC over MIC and time above MIC, also need the MIC for each organism, which WinNonlin does not predict. That number comes from a susceptibility assay or a potency model.
Pricing
Published, monthly, and on this page
Lab is $149 a month for 250 screens with batches up to 50 compounds, which is $1,788 across a year. Discovery is $499 for 2,000 screens, batches up to 1,000, and adds the API. Program is $1,490 for 10,000 screens with batches up to 10,000. The 2024 per seat WinNonlin figure would pay for about 4.9 years of Lab, and one year of the FDA's current Phoenix agreement for 93. That comparison is fair only when the potency answer is the one you need first.
Yearly billing is two months cheaper, charged once a year.
Lab
$124 /mo
$1,488 charged once a year
250 screens a month against the standard panels, with CSV export.
Get startedAcademic AMR lab, 1 to 2 chemists
Discovery
Most popular$416 /mo
$4,992 charged once a year
Custom panels, batch runs of a full series, API access and roles.
Get startedBiotech antibacterial program
Program
$1,241 /mo
$14,892 charged once a year
Library-scale runs, your own isolates, SSO, audit log and an SLA.
Get startedMulti-program biotech or discovery CRO
Enterprise
Talk to sales
Custom terms, invoiced
Private deployment, your internal isolate library, a named contact.
Pharma, institute or consortium
Get the MIC before you pay for the AUC
Paste a compound you already know the MIC for, read the panel, then decide which compounds are worth a PK study.
What you are agreeing to
- Your compounds stay yours
- Never used for model training
- Deletable on request
- No card needed to create your account
Related reading
The pages behind the calls a screening budget has to make.